Huntington's Disease Research - Genetics, Causes, Symptoms, Treatment

Huntington's Disease Research Today is a free monthly online journal that collates and summarizes the latest research about Huntington's Disease, including details on genetics, causes, symptoms, treatment.


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Recommended Books on Huntington's Disease

Huntington Disease - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References Huntington Disease - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References In March 2001, the National Institutes of Health issued the following warning: "The number of Web sites offering health-related resources grows every day. Many sites provide valuable information, while others may have information that is unreliable or misleading." Furthermore, because of the rapid increase in Internet-based information, many hours can be wasted searching, selecting, and printing.This book was created for medical professionals, students, and members of the general public who want to conduct medical research using the most advanced tools available and spending the least amount of time doing so.

Huntington's Disease: Early Detection & Progression of Cognitive Changes in Patients & Asymptomatic Mutation Carriers (Acta Biomedica Lovaniensia) Huntington's Disease: Early Detection & Progression of Cognitive Changes in Patients & Asymptomatic Mutation Carriers (Acta Biomedica Lovaniensia) This is a Ph.D. dissertation. Huntington's Disease (HD) is a dominantly inherited late onset neurodegenerative disorder, initially affecting the basal ganglia and especially the head of the caudate nucleus.

Eventually, atrophy is more diffuse extending to the cerebral cortex and other brain nuclei. A triad of progressive motor, cognitive, and emotional symptoms characterizes adult onset HD.

Contents include: General Introduction and Aims of the Study, Cognitive Changes in Patients with HD and Asymptomatic Carriers of the HD Mutation, Recent Memory and Recognition Memory in Huntington's Disease, Habitual Learning

Blue Institution Blue Institution Scott Porter, institutionalized at the age of twenty in a state institution for the developmentally delayed. Ironically, Scott is not developmentally delayed. He suffers from a hereditary neurological disease, Huntington's chorea, which Scott admits is "one of Mother Nature's cruelest jokes."Huntington's has rendered Scott virtually unable to do anything for himself, including communicating verbally. The only communication he has is the subtle vibrations in a person's being, that only a handful of the more sensitive care-givers, where he now lives, understand. Scott's brilliant mind is still intact, it's his body that doesn't want to function any-longer.So with all the problems that Scott has, how does he tell his story? "It's a miracle." Scott tells his story through his mind-his thoughts-in a no holds barred, down to earth style that is humorously entertaining, but he can not hide his constant struggle with a deep depression and loneliness.Blue Institution illustrates the tragedy of one individual coping and dying from Huntington's chorea, and how its tragedy touched the lives of his family and care-givers. Through Scott's eyes, it is a timeless witness, portraying life in a state institution for the developmentally delayed, in the mid nineteen-seventies and eighties.

Episodic memory impairment in Huntington's disease: A meta-analysis [An article from: Neuropsychologia] Episodic memory impairment in Huntington's disease: A meta-analysis [An article from: Neuropsychologia] This digital document is a journal article from Neuropsychologia, published by Elsevier in 2006. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.

Description:
Memory dysfunction is an important feature in the clinical presentation of Huntington's disease (HD) and may precede the onset of motor symptoms. Although several studies have contributed to the quantitative and qualitative description of memory impairments in HD, the characterization of episodic memory impairments has varied considerably. Whereas most studies report significant impairments on free recall tests, performance on recognition tests has been considerably more variable, ranging from normal to markedly deficient. This absence of a well-established recognition memory deficit has led some investigators to attribute the memory deficits in HD to a retrieval-based episodic memory impairment. We felt that a quantitative review of the literature was needed to better characterize these episodic memory impairments. We conducted a meta-analysis to assess the magnitude of the recognition memory deficit in HD and to examine it in relation to the known deficit in recall. Memory data were provided by 544 symptomatic HD patients, 224 presymptomatic gene-carriers, and 963 control subjects. The overall group comparison between symptomatic patients and controls yielded effect sizes of d=1.95 for free recall and d=1.73 for recognition. We split the symptomatic group into two subgroups based on their mental status (mild and moderate/severe dementia) and both showed significant deficits in recall and recognition memory, though recall was more impaired than recognition in the mild dementia subgroup. Only slight memory impairment was observed in the presymptomatic subjects. The results show that deficits in recognition memory must be accounted for in future models of memory impairment in HD.

Disgust in pre-clinical Huntington's disease: A longitudinal study [An article from: Neuropsychologia] Disgust in pre-clinical Huntington's disease: A longitudinal study [An article from: Neuropsychologia] This digital document is a journal article from Neuropsychologia, published by Elsevier in . The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.

Description:
Emotion recognition from both face and voice and experience of emotions were investigated in a group of non-symptomatic people at risk of carrying the Huntington's disease gene who presented for genetic testing. Based on the results of the DNA test, a group of people carrying the Huntington's disease gene (HD+), and a group of non-carriers (HD-) were formed. Since we were especially interested in the time course of possible deficits in emotion recognition, all people at risk were reassessed 6 and 12months after the initial assessment. Recognising facial expressions of disgust was significantly impaired on all three assessments in the HD+ group, while recognition of vocal emotions and the experience of emotions were largely unaffected, confirming that deficits in recognition of facial expressions of disgust are an early correlate of carrying the gene for Huntington's disease. The inclusion of a healthy control group (n=37) further allowed an estimate of the genetic and environmental contribution to deficits in facial emotion recognition.

Huntington Disease - A Bibliography and Dictionary for Physicians, Patients, and Genome Researchers Huntington Disease - A Bibliography and Dictionary for Physicians, Patients, and Genome Researchers In March 2001, the National Institutes of Health issued the following warning: "The number of Web sites offering health-related resources grows every day. Many sites provide valuable information, while others may have information that is unreliable or misleading." Furthermore, because of the rapid increase in Internet-based information, many hours can be wasted searching, selecting, and printing. Since only the smallest fraction of information dealing with Huntington disease is indexed in search engines, such as www.google.com or others, a non-systematic approach to Internet research can be not only time consuming, but also incomplete. This book was created for medical professionals, students, and members of the general public who want to conduct medical research using the most advanced tools available and spending the least amount of time doing so.

Huntington's Disease (Genes and Disease) Huntington's Disease (Genes and Disease) Huntington's disease, or Huntington's chorea, is a progressive genetic disease marked by death of brain cells coupled with loss of muscular control and coordination, declining mental abilities, and erratic behavior. Currently, this form of dementia has no cure. "Huntington's Disease" introduces this disease, detailing its history and progression, and discusses the search for the gene that causes it and the development of genetic tests for the gene. This title also addresses the ethical questions of testing people for a disease whose symptoms typically develop later in life.

Juvenile Huntington's Disease: and other trinucleotide repeat disorders Juvenile Huntington's Disease: and other trinucleotide repeat disorders Huntington's Disease (HD) is an inherited progressive neurodegenerative disorder. Although onset of Huntington's Disease usually occurs in adulthood, the age of onset of the condition is extremely variable with approximately 5-10% of cases having an onset of less than 20 years, or Juvenile Huntington's Disease (JHD). While JHD shares many of the clinical features of adult HD (e.g., chorea and personality disorders), patients with JHD often experience additional problems including seizures, dystonia, and Parkinsonism. Diagnosis in patients with JHD is often delayed because of the failure of clinicians to recognize the characteristic features of the condition. While several textbooks have been published on HD, no books have been published to date focusing solely on the juvenile onset form of the disease. This book summarizes, for the first time, the clinical and scientific knowledge available on JHD. It also collects together accounts from families affected by the condition, putting the clinical and scientific chapters into context.
Edited by members of the working party European Huntington's Disease Network (EDHN), this book forms the first comprehensive text on JHD and is of interest to neurologists, geneticists, academic/research scientists, and other healthcare professionals.

Huntington's Disease - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References Huntington's Disease - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References In March 2001, the National Institutes of Health issued the following warning: "The number of Web sites offering health-related resources grows every day. Many sites provide valuable information, while others may have information that is unreliable or misleading." Furthermore, because of the rapid increase in Internet-based information, many hours can be wasted searching, selecting, and printing.This book was created for medical professionals, students, and members of the general public who want to conduct medical research using the most advanced tools available and spending the least amount of time doing so.

Huntington's Disease (Oxford Monographs on Medical Genetics, 45) Huntington's Disease (Oxford Monographs on Medical Genetics, 45) It is now almost a decade since the identification of the Huntington's Disease gene and its mutation. Major advances in our understanding of the disorder have been made during this time. Since publication of the first two editions, much more extensive evidence exists on how the HD mutation actually causes brain pathology. Experimental tools are now available to take this research further towards new therapeutic approaches. Due to these major changes, this well-established book has been radically updated. An international group of leaders in their particular fields cover the major recent advances in the genetics and neurobiology of the disease. Developments in our understanding of how the molecular basis of the disorder results in brain degeneration, with full coverage of transgenic animal models, neurochemical studies and advances in neuropathology are discussed in detail. The clinical sections cover both neurological and psychiatric aspects as well as new developments in therapy. This book will continue to provide an invaluable source of information for clinicians and scientists involved with Huntington's Disease, including geneticists, psychiatrists and neurologists and basic research workers in genetics and neurobiology.

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Huntington's Disease Research Today Archive:

Volume 1 (2005)
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Volume 2 (2006)
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Volume 3 (2007)
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Volume 4 (2008)
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Volume 5 (2009)
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Volume 6 (2010)
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Volume 7 (2011)
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Volume 8 (2012)
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Volume 9 (2013)
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Huntington's Disease Books

Episodic memory impairment in Huntington's disease: A meta-analysis [An article from: Neuropsychologia]

Episodic memory impairment in Huntington's disease: A meta-analysis [An article from: Neuropsychologia]