Huntington's Disease Research Today is a free monthly online journal that collates and summarizes the latest research about Huntington's Disease, including details on genetics, causes, symptoms, treatment.

Identification of an oculomotor biomarker of preclinical Huntington disease.

Golding CV, Danchaivijitr C, Hodgson TL, Tabrizi SJ, Kennard C

Department of Clinical Neuroscience, Faculty of Medicine, Imperial College, London, UK. c.golding@imperial.ac.uk

The authors examined oculomotor function to identify a biomarker of disease progression in genetically confirmed preclinical and early clinical Huntington disease (HD). Initiation deficits of voluntary-guided, but not reflexive, saccades were characteristic of preclinical HD. Saccadic slowing and delayed reflexive saccades were demonstrated in clinical but not preclinical HD. Saccadic measures provide biomarkers of disease progression in both preclinical and early clinical stages of HD.

Published 8 August 2006 in Neurology, 67(3): 485-7.
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