Huntington's Disease Research Today is a free monthly online journal that collates and summarizes the latest research about Huntington's Disease, including details on genetics, causes, symptoms, treatment.

Increased rate of whole-brain atrophy over 6 months in early Huntington disease.

Henley SM, Frost C, MacManus DG, Warner TT, Fox NC, Tabrizi SJ

Dementia Research Centre, Institute of Neurology, University College London, London, UK.

The authors measured the rate of whole-brain atrophy over 6 months in 13 patients with early Huntington disease (HD) and seven matched controls. Patients with early HD had significantly increased rates of whole-brain atrophy vs controls (mean [SD] HD, 1.10 [0.88]%/year; controls, 0.26 [0.54]%/year). The measurement of cerebral change over short time periods (e.g., 6 months) may be relevant for trials designed to assess effects on neurodegeneration or atrophy.

Published 22 August 2006 in Neurology, 67(4): 694-6.
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