Huntington's Disease Research Today is a free monthly online journal that collates and summarizes the latest research about Huntington's Disease, including details on genetics, causes, symptoms, treatment.

Regional cortical thinning in preclinical Huntington disease and its relationship to cognition.

Rosas HD, Hevelone ND, Zaleta AK, Greve DN, Salat DH, Fischl B

Department of Neurology, Center for Neuroimaging of Aging and Neurodegenerative Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. rosas@helix.mgh.harvard.edu

The authors studied presymptomatic individuals with the Huntington disease (HD) mutation to determine whether cortical thinning was present. They found thinning that was regionally selective, semi-independent of striatal volume loss, and correlated with cognitive performance. Early, extensive cortical involvement occurs during the preclinical stages of HD.

Published 13 September 2005 in Neurology, 65(5): 745-7.
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