Huntington's Disease Research Today is a free monthly online journal that collates and summarizes the latest research about Huntington's Disease, including details on genetics, causes, symptoms, treatment.

The power of the dark side: Huntington's disease protein and p53 form a deadly alliance.

La Spada AR, Morrison RS

Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA.

A role for apoptotic mediators in neurodegenerative disease has long been considered, but the identity of the putative effectors and the basis of their actions in neurodegeneration remain ill-defined. Huntington's disease (HD) is a polyglutamine disorder whose pathogenesis likely involves mitochondrial dysfunction. In this issue of Neuron, Bae et al. present data implicating p53 in HD pathogenesis. This intriguing study may thus provide a link between nuclear transcription dysregulation and mitochondrial abnormalities in HD.

Published 5 July 2005 in Neuron, 47(1): 1-3.
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